Blar i forfatter "Andreassen, Arne K."

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    • The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection 

      Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-19)
      <p><i>BACKGROUND - </i>Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated if circulating γBB, TMAO, and their common precursors carnitine and trimethyllysine (TML) were dysregulated after heart transplantation and associated with development ...

    • Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression 

      Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari; Olsen, Maria Belland; Kong, Xiang Yi; Gude, Einar; Andreassen, Arne K.; Solbu, Dag; Karason, Kristjan; Dellgren, Göran; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel, 2018-10-12)
      Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) ...

    • Circulating regulators of the wingless pathway in precapillary pulmonary hypertension 

      Ueland, Thor; Abraityte, Aurelija; Norum, Hilde; Varathalingam, Sharanga; Gullestad, Lars; Aukrust, Pål; Andreassen, Arne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
      Background and objective - Dysregulated Wnt signalling has been implicated in pulmonary hypertension (PH). We hypothesized that plasma levels of secreted Wnt proteins would be increased in patients with precapillary PH, correlate with indices of vascular resistance and cardiac function and give information on long-term prognosis.<p> <p>Methods - We measured the Wnt ligand Wnt5a and secreted Wnt ...

    • Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension 

      Lekva, Tove; Gullestad, Lars; Broch, Kaspar; Aukrust, Pål; Andreassen, Arne K.; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-29)
      Activation of inflammatory processes has been identified as a major driver of pulmonary vascular remodeling that contributes to the development of precapillary pulmonary hypertension (PH). We hypothesized that circulating markers of leukocyte activation, reflecting monocytes/macrophages (sCD163, sCD14), T-cells (sCD25) and neutrophils (myeloperoxidase [MPO], neutrophil gelatinase-associated lipocalin ...

    • Effect of everolimus initiation and calcineurin inhibitor elimination on cardiac allograft vasculopathy in de novo heart transplant recipients - Three-Year results of a Scandinavian randomized trial 

      Arora, Satish; Andreassen, Arne K.; Karason, Kristjan; Gustafsson, Finn; Eiskjær, Hans; Bøtker, Hans Erik; Rådegran, Göran; Gude, Einar; Ioanes, Dan; Solbu, Dag; Dellgren, Göran; Ueland, Thor; Aukrust, Pål; Gullestad, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-07)
      <i>Background</i>: Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation, and the effect of different immunosuppressive regimens on CAV is not fully understood. The randomized SCHEDULE trial (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) evaluated whether initiation of the proliferation signal inhibitor ...